Compounds > 5-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide
Page last updated: 2024-12-09

5-(1,3-benzodioxol-5-yl)-N-(2-furanylmethyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID645580
CHEMBL ID1527746
CHEBI ID105455
SCHEMBL ID1717790

Synonyms (21)

Synonym
5-benzo[1,3]dioxol-5-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (furan-2-ylmethyl)-amide
MLS000072642 ,
TG2-185-1-1
smr000010609
5-(1,3-benzodioxol-5-yl)-n-(furan-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
STK338595
MLS002534618
CHEBI:105455
AKOS000556763
HMS2414A17
SCHEMBL1717790
5-(1,3-benzodioxol-5-yl)-n-(2-furfuryl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
cid_645580
bdbm40268
5-(1,3-benzodioxol-5-yl)-n-(2-furanylmethyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinecarboxamide
CHEMBL1527746
Q27183190
SR-01000369430-1
sr-01000369430
grvohzqlizjklw-uhfffaoysa-n
cid 645580
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyrazolopyrimidine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (26)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency7.94330.003245.467312,589.2998AID2517
Chain A, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID893
Chain B, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID893
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency89.12510.631035.7641100.0000AID504339
Chain A, CruzipainTrypanosoma cruziPotency39.81070.002014.677939.8107AID1476
acid sphingomyelinaseHomo sapiens (human)Potency25.118914.125424.061339.8107AID504937
glp-1 receptor, partialHomo sapiens (human)Potency28.18380.01846.806014.1254AID624417
ClpPBacillus subtilisPotency35.48131.995322.673039.8107AID651965
phosphopantetheinyl transferaseBacillus subtilisPotency10.00000.141337.9142100.0000AID1490
ATAD5 protein, partialHomo sapiens (human)Potency35.48130.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency17.35820.000811.382244.6684AID686978; AID686979
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency11.22020.011212.4002100.0000AID1030
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency7.94330.001815.663839.8107AID894
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency1.15820.00419.984825.9290AID504444
importin subunit beta-1 isoform 1Homo sapiens (human)Potency64.46795.804836.130665.1308AID540253; AID540263
DNA polymerase betaHomo sapiens (human)Potency79.43280.022421.010289.1251AID485314
snurportin-1Homo sapiens (human)Potency64.46795.804836.130665.1308AID540253; AID540263
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency39.81075.804816.996225.9290AID540253
gemininHomo sapiens (human)Potency18.35640.004611.374133.4983AID624296; AID624297
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency39.81070.00419.962528.1838AID2675
caspase-1 isoform alpha precursorHomo sapiens (human)Potency31.62280.000311.448431.6228AID900
lamin isoform A-delta10Homo sapiens (human)Potency10.00000.891312.067628.1838AID1487
Caspase-7Homo sapiens (human)Potency31.62283.981118.585631.6228AID889
Guanine nucleotide-binding protein GHomo sapiens (human)Potency44.66841.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Ubiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)IC50 (µMol)24.168715.440019.715223.3297AID1068; AID1134; AID714
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
G-protein coupled receptor 55Homo sapiens (human)EC50 (µMol)32.00000.26301.54937.3536AID1961
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (51)

Processvia Protein(s)Taxonomy
proteolysisCaspase-7Homo sapiens (human)
apoptotic processCaspase-7Homo sapiens (human)
heart developmentCaspase-7Homo sapiens (human)
response to UVCaspase-7Homo sapiens (human)
protein processingCaspase-7Homo sapiens (human)
protein catabolic processCaspase-7Homo sapiens (human)
defense response to bacteriumCaspase-7Homo sapiens (human)
fibroblast apoptotic processCaspase-7Homo sapiens (human)
striated muscle cell differentiationCaspase-7Homo sapiens (human)
neuron apoptotic processCaspase-7Homo sapiens (human)
protein maturationCaspase-7Homo sapiens (human)
lymphocyte apoptotic processCaspase-7Homo sapiens (human)
cellular response to lipopolysaccharideCaspase-7Homo sapiens (human)
cellular response to staurosporineCaspase-7Homo sapiens (human)
execution phase of apoptosisCaspase-7Homo sapiens (human)
positive regulation of plasma membrane repairCaspase-7Homo sapiens (human)
positive regulation of neuron apoptotic processCaspase-7Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
mitotic cell cycleUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
regulation of cell growthUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
in utero embryonic developmentUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
tissue homeostasisUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
thrombocyte differentiationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
chromatin remodelingUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
ubiquitin-dependent protein catabolic processUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
negative regulation of cell population proliferationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
response to inorganic substanceUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
gene expressionUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
protein deubiquitinationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
neutrophil differentiationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
myeloid cell apoptotic processUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
monoubiquitinated protein deubiquitinationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
common myeloid progenitor cell proliferationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
protein modification processUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
platelet morphogenesisUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
erythrocyte maturationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
nucleate erythrocyte differentiationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
negative regulation of DNA-templated transcriptionUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
regulation of inflammatory responseUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
regulation of cell cycleUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
hematopoietic stem cell homeostasisUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
macrophage homeostasisUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
neuron cellular homeostasisUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
leukocyte proliferationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
protein K48-linked deubiquitinationUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
regulation of cytokine production involved in inflammatory responseUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
positive regulation of protein targeting to mitochondrionUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (14)

Processvia Protein(s)Taxonomy
RNA bindingCaspase-7Homo sapiens (human)
aspartic-type endopeptidase activityCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activityCaspase-7Homo sapiens (human)
protein bindingCaspase-7Homo sapiens (human)
peptidase activityCaspase-7Homo sapiens (human)
cysteine-type peptidase activityCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic processCaspase-7Homo sapiens (human)
cysteine-type endopeptidase activity involved in execution phase of apoptosisCaspase-7Homo sapiens (human)
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
chromatin bindingUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
cysteine-type deubiquitinase activityUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
protein bindingUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
peptidase activityUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
chromatin DNA bindingUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
histone H2A deubiquitinase activityUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (7)

Processvia Protein(s)Taxonomy
extracellular spaceCaspase-7Homo sapiens (human)
nucleusCaspase-7Homo sapiens (human)
cytoplasmCaspase-7Homo sapiens (human)
cytosolCaspase-7Homo sapiens (human)
nucleusCaspase-7Homo sapiens (human)
nucleoplasmCaspase-7Homo sapiens (human)
cytosolCaspase-7Homo sapiens (human)
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
nucleusUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
nucleoplasmUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
cytoplasmUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
cytosolUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
PR-DUB complexUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
cytoplasmUbiquitin carboxyl-terminal hydrolase BAP1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510